Abbas immunology pdf free
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This work aims to analyze the role of these ATRs in meningococcal sepsis and to identify possible underlying mechanisms. However, the roles of ATRs C3aR and C5aR2 in IMD are still unclear.
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It has already been shown that blocking the ATR C5aR1 strongly benefitted the outcome of IMD in a murine sepsis model. There are three anaphylatoxin receptors (ATRs), the C3aR, the C5aR1 and the C5aR2, capable of detecting these anaphylatoxins. A hallmark of IMD is an overreaction of the immune system and the release of the potent anaphylatoxins C3a and C5a by the complement system is an important factor hereby. In addition to the direct bacterial killing, the complement system is also an important player in different inflammatory processes. The complement cascade is activated through different pathogen associated patterns and finally leads to the lysis of the bacteria by the membrane attack complex. The most important immune defense mechanism in invasive meningococcal disease (IMD) is the complement mediated killing of bacteria. Upon becoming invasive, Nme can cause meningitis and life-threatening sepsis. The human specific gram-negative bacterium Neisseria meningitidis (Nme, meningococci) is a common colonizer of the upper respiratory tract.